Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 3/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.37 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696423 | 0.93 | EIF4A3 (0.46) | SPRNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL5230484 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL5239352 | 0.80 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL4694593 | 0.79 | ALDH1A1 (0.41) | RAB9AHPGDALDH1A1NPSR1HCRTR1 | |
| SCHEMBL5238002 | 0.79 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL5238361 | 0.78 | HPGD (0.43) | RAB9AHPGD | |
| SCHEMBL4692413 | 0.78 | HCRTR1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL5231911 | 0.78 | HCRTR1 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL5232235 | 0.77 | HCRTR2 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL4968486 | 0.77 | HCRTR1 (0.42) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |