Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189990 | 0.78 | NR4A2 (0.41) | CFTRMKNK1MKNK2EPHX2MAPT | |
| SCHEMBL4023313 | 0.76 | PTGES (0.40) | PLK1PLK3MKNK1MKNK2EPHX2 | |
| SCHEMBL29834882 | 0.62 | HDAC6 (0.51) | HDAC1HDAC6ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27653888 | 0.59 | NR1H2 (0.69) | — | |
| SCHEMBL1125399 | 0.58 | NR1H2 (0.83) | SCN5ASCN9A | |
| SCHEMBL12613920 | 0.57 | KDM4E (0.46) | HDAC6MKNK1MKNK2ALDH1A1 | |
| SCHEMBL105728 | 0.57 | ADRA2A (0.53) | SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL29834889 | 0.56 | NR4A2 (0.47) | CFTRALDH1A1 | |
| SCHEMBL11235065 | 0.56 | FABP4 (0.50) | ALDH1A1 | |
| SCHEMBL29995840 | 0.56 | CYP11B2 (0.49) | HDAC6ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765775-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123675-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2005-12-29 | — | — | WO | disclosed |