Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237020 | 0.86 | MGLL (0.47) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL5234118 | 0.85 | DHODH (0.41) | CNR2MAPTSMN1; SMN2 | |
| SCHEMBL5231147 | 0.83 | CNR2 (0.48) | CNR2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5232329 | 0.81 | LMNA (0.48) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5233010 | 0.81 | MGLL (0.44) | — | |
| SCHEMBL5238879 | 0.77 | CNR2 (0.67) | CNR2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5238349 | 0.77 | MAPT (0.45) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5237326 | 0.74 | CA2 (0.43) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5233779 | 0.74 | CA12 (0.41) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5237578 | 0.72 | KDM4E (0.43) | CNR2MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |