Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.38 |
| ▸ | ME1 | P48163 | 1/20 | 0.38 |
| ▸ | ME3 | Q16798 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233779 | 0.97 | CA12 (0.41) | CA2CA12CA9AKR1C3NOTUM | |
| SCHEMBL5232288 | 0.86 | MAPT (0.41) | CA2CA12CA9AKR1C3NOTUM | |
| SCHEMBL5232329 | 0.86 | LMNA (0.48) | NOTUMMAPTSMN1; SMN2MEN1TSHR | |
| SCHEMBL5232200 | 0.86 | SLC6A7 (0.42) | MAPTSMN1; SMN2MEN1TSHRHTT | |
| SCHEMBL5239779 | 0.85 | MAPT (0.40) | AKR1C3MAPTSMN1; SMN2MMP2MMP13 | |
| SCHEMBL5238186 | 0.85 | CYP2C19 (0.43) | MAPTMEN1TSHRHTTKMT2A | |
| SCHEMBL5230475 | 0.84 | CYP2C9 (0.44) | MEN1TSHRKMT2A | |
| SCHEMBL5239092 | 0.84 | MEN1 (0.41) | CA2CA12CA9AKR1C3NOTUM | |
| SCHEMBL5234836 | 0.83 | MEN1 (0.43) | CA2CA12CA9MAPTSMN1; SMN2 | |
| SCHEMBL5236546 | 0.83 | USP2 (0.46) | MAPTSMN1; SMN2MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |