Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 10/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237027 | 0.87 | MGLL (0.44) | SLC6A7 | |
| SCHEMBL5234121 | 0.87 | DHODH (0.39) | CNR2SLC6A7 | |
| SCHEMBL5232205 | 0.84 | SLC6A7 (0.41) | NPC1MAPTSMN1; SMN2LMNASLC6A7 | |
| SCHEMBL5231133 | 0.83 | CNR2 (0.51) | CNR2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5232337 | 0.83 | LMNA (0.45) | RAB9AMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5233015 | 0.83 | MGLL (0.42) | SLC6A7 | |
| SCHEMBL5238354 | 0.79 | MAPT (0.40) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5237329 | 0.77 | CA2 (0.40) | MAPTSMN1; SMN2THRBLMNATP53 | |
| SCHEMBL5238879 | 0.75 | CNR2 (0.67) | CNR2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5238652 | 0.74 | HSD17B10 (0.44) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |