Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MITF | O75030 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232920 | 0.89 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2PKMKDM4E | |
| SCHEMBL5238328 | 0.85 | THRB (0.44) | NPC1RAB9ASMN1; SMN2PKMKDM4E | |
| SCHEMBL5236574 | 0.80 | TSHR (0.48) | SMN1; SMN2PKMKDM4EKMT2AGRM4 | |
| SCHEMBL5231726 | 0.80 | GRM4 (0.44) | NPC1RAB9ASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL4872056 | 0.79 | CYP1A2 (0.55) | KDM4EKMT2AGRM4LMNAHTT | |
| SCHEMBL4873486 | 0.77 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2PKMKDM4E | |
| SCHEMBL5235795 | 0.74 | KDR (0.45) | NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL5233499 | 0.74 | GRM4 (0.43) | NPC1SMN1; SMN2KDM4EMAPTKMT2A | |
| SCHEMBL6703618 | 0.73 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2PKMKDM4E | |
| SCHEMBL5923675 | 0.72 | FERMT2 (0.46) | NPC1RAB9ASMN1; SMN2PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2004026302-A1 | METHODS OF INHIBITING TGF BETA WITH SUBSTITUTED PYRAZOLES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |