SCHEMBL5232934

SCHEMBL5232934

CC(C)N(c1nn(-c2ccc(N(C)C)cc2)cc1OC(=O)O)C(=O)[C@H]1CC[C@H](C)CC1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5236797 0.90
SCHEMBL5236128 0.90 NPC1 (0.34) KDM4EALDH1A1
SCHEMBL5233446 0.90 NPC1 (0.35) KDM4EALDH1A1
SCHEMBL5239459 0.89 KDM4E (0.33) KDM4EALDH1A1
SCHEMBL5231776 0.89 ESRRA (0.32) KDM4EALDH1A1
SCHEMBL5234344 0.89 ESRRA (0.31)
SCHEMBL5234220 0.89 HRH3 (0.31) ALDH1A1
SCHEMBL5234129 0.89 ADORA3 (0.37) KDM4EALDH1A1
SCHEMBL5233835 0.89 KCNJ1 (0.32) ALDH1A1
SCHEMBL5238208 0.89 ALDH1A1 (0.38) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1730116-B1 4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS SMITHKLINE BEECHAM CORP (US) 2007-09-05 EP claimed