Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234475 | 0.89 | MGLL (0.48) | SMN1; SMN2MAPTKDM4EMGLLDGAT1 | |
| SCHEMBL5238349 | 0.84 | MAPT (0.45) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5236231 | 0.82 | MAPT (0.43) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5233246 | 0.81 | MGLL (0.42) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5233583 | 0.79 | CKS1B (0.41) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5237578 | 0.79 | KDM4E (0.43) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5238354 | 0.77 | MAPT (0.40) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5232948 | 0.77 | MGLL (0.60) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5236239 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTKDM4EMGLLHPGD | |
| SCHEMBL5237020 | 0.74 | MGLL (0.47) | SMN1; SMN2MAPTKDM4EMGLLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |