Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238349 | 0.90 | MAPT (0.45) | MAPTKDM4ESMN1; SMN2HPGDMGLL | |
| SCHEMBL5233583 | 0.89 | CKS1B (0.41) | MAPTKDM4ESMN1; SMN2HPGDMGLL | |
| SCHEMBL5237578 | 0.84 | KDM4E (0.43) | MAPTKDM4ESMN1; SMN2HPGDMGLL | |
| SCHEMBL5236239 | 0.83 | SMN1; SMN2 (0.41) | MAPTKDM4ESMN1; SMN2HPGDMGLL | |
| SCHEMBL5237938 | 0.82 | PANK3 (0.41) | MAPTSMN1; SMN2HPGDPANK3MEN1 | |
| SCHEMBL5233237 | 0.82 | SMN1; SMN2 (0.44) | MAPTKDM4ESMN1; SMN2HPGDMGLL | |
| SCHEMBL5237020 | 0.80 | MGLL (0.47) | MAPTKDM4ESMN1; SMN2MGLLLMNA | |
| SCHEMBL5238939 | 0.78 | MCHR1 (0.39) | — | |
| SCHEMBL5238354 | 0.77 | MAPT (0.40) | MAPTKDM4ESMN1; SMN2HPGDMGLL | |
| SCHEMBL5236755 | 0.77 | MGLL (0.41) | MAPTSMN1; SMN2MGLLLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |