Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 11/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236231 | 0.89 | MAPT (0.43) | MAPTKDM4EDGAT1KCNH2CYP2C9 | |
| SCHEMBL5238349 | 0.86 | MAPT (0.45) | MAPTKDM4EDGAT1KCNH2CYP2C9 | |
| SCHEMBL5233805 | 0.84 | PANK3 (0.39) | CKS1BSKP1SKP2 | |
| SCHEMBL5233588 | 0.83 | DGAT1 (0.41) | CKS1BSKP1SKP2MAPTKDM4E | |
| SCHEMBL5237578 | 0.81 | KDM4E (0.43) | MAPTKDM4EDGAT1KCNH2MGLL | |
| SCHEMBL5233237 | 0.79 | SMN1; SMN2 (0.44) | MAPTKDM4EDGAT1KCNH2CYP2C9 | |
| SCHEMBL5237020 | 0.77 | MGLL (0.47) | MAPTKDM4EDGAT1KCNH2MGLL | |
| SCHEMBL5238939 | 0.75 | MCHR1 (0.39) | CHRM2CHRM1 | |
| SCHEMBL5236239 | 0.75 | SMN1; SMN2 (0.41) | MAPTKDM4EDGAT1KCNH2CYP2C9 | |
| SCHEMBL5238354 | 0.74 | MAPT (0.40) | MAPTKDM4EDGAT1KCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |