Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236783 | 0.89 | LMNA (0.43) | LMNASMN1; SMN2MCOLN3HTTRAB9A | |
| SCHEMBL5234362 | 0.86 | LMNA (0.41) | LMNASMN1; SMN2MCOLN3HTTRAB9A | |
| SCHEMBL28785424 | 0.83 | F2 (0.37) | HTTRAB9ACA1CA2MMP1 | |
| SCHEMBL5230088 | 0.82 | RAPGEF4 (0.42) | LMNASMN1; SMN2HTTRAB9AL3MBTL1 | |
| SCHEMBL5232759 | 0.81 | RAPGEF4 (0.38) | SMN1; SMN2CA1CA2MMP1MMP2 | |
| SCHEMBL5230249 | 0.76 | TCF4 (0.38) | LMNASMN1; SMN2HTTRAB9ACA1 | |
| SCHEMBL5235759 | 0.74 | LMNA (0.45) | LMNASMN1; SMN2HTTRAB9ACA1 | |
| SCHEMBL5236778 | 0.74 | LMNA (0.43) | LMNASMN1; SMN2MCOLN3HTTRAB9A | |
| SCHEMBL28521918 | 0.73 | F2 (0.36) | LMNASMN1; SMN2MCOLN3HTTCA1 | |
| Hydroxyamine SCHEMBL259333 | 0.73 | CA1 (0.54) | LMNARAB9ACA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |