Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233246 | 0.90 | MGLL (0.42) | MGLLSLC6A7KCNH2CYP2C9DGAT1 | |
| SCHEMBL5237027 | 0.85 | MGLL (0.44) | MGLLSLC6A7GRIN2BKCNH2CYP2C9 | |
| SCHEMBL5236715 | 0.83 | KDM1A (0.39) | SLC6A7GRIN2BKCNH2CYP2C9GRIN1 | |
| SCHEMBL5234475 | 0.83 | MGLL (0.48) | MGLLSLC6A7GRIN2BKCNH2GRIN1 | |
| SCHEMBL5233015 | 0.81 | MGLL (0.42) | MGLLSLC6A7GRIN2BKCNH2CYP2C9 | |
| SCHEMBL5237020 | 0.78 | MGLL (0.47) | MGLLSLC6A7GRIN2BKCNH2GRIN1 | |
| SCHEMBL5232330 | 0.77 | MGLL (0.64) | MGLLSLC6A7GRIN2BKCNH2CYP2C9 | |
| SCHEMBL5238354 | 0.75 | MAPT (0.40) | MGLLKCNH2CYP2C9DGAT1CYP3A4 | |
| SCHEMBL5236239 | 0.74 | SMN1; SMN2 (0.41) | MGLLKCNH2CYP2C9DGAT1CYP3A4 | |
| SCHEMBL5237745 | 0.73 | MGLL (0.60) | MGLLSLC6A7GRIN2BKCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |