Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234121 | 0.86 | DHODH (0.39) | KDM1AMAOBSLC6A7DHODHKMO | |
| SCHEMBL5234482 | 0.83 | MGLL (0.46) | SLC6A7APPGRIN2BCYP2C9GRIN1 | |
| SCHEMBL5236708 | 0.83 | KDM1A (0.41) | KDM1AMAOBSLC6A7DHODHKMO | |
| SCHEMBL5234118 | 0.78 | DHODH (0.41) | KDM1AMAOBSLC6A7DHODHKMO | |
| SCHEMBL5230452 | 0.77 | SLC6A7 (0.49) | KDM1AMAOBSLC6A7DHODHKMO | |
| SCHEMBL5233246 | 0.75 | MGLL (0.42) | SLC6A7KDM4ELMNAMAPTHTT | |
| SCHEMBL5232205 | 0.73 | SLC6A7 (0.41) | KDM1AMAOBSLC6A7MAOAKDM4E | |
| SCHEMBL5231147 | 0.72 | CNR2 (0.48) | SLC6A7LMNAMAPTMEN1NPC1 | |
| SCHEMBL5236251 | 0.71 | KCNA5 (0.39) | — | |
| SCHEMBL594736 | 0.70 | LMNA (0.50) | KDM1AMAOBSLC6A7MAOAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |