Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL523389 | 0.94 | PRCP (0.42) | PRCPMEN1KMT2ABLMDPP4 | |
| Octanol SCHEMBL1850228 | 0.92 | PRCP (0.57) | PRCPMEN1KMT2ABLMALDH1A1 | |
| Proline SCHEMBL6113018 | 0.90 | MEN1 (0.45) | PRCPMEN1KMT2ABLMDPP4 | |
| Proline SCHEMBL6113021 | 0.90 | MEN1 (0.45) | PRCPMEN1KMT2ABLMDPP4 | |
| Proline SCHEMBL10141181 | 0.85 | — | — | |
| Proline SCHEMBL10141185 | 0.85 | — | — | |
| Proline SCHEMBL462225 | 0.85 | BLM (0.52) | PRCPMEN1KMT2ABLMDPP4 | |
| D-Proline SCHEMBL21462052 | 0.85 | BLM (0.52) | PRCPMEN1KMT2ABLMDPP4 | |
| Proline SCHEMBL462226 | 0.85 | BLM (0.52) | PRCPMEN1KMT2ABLMDPP4 | |
| Proline SCHEMBL13248912 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027859-A1 | Biodegradable Proline-Based Polymers | MEDIVAS, LLC | 2012-02-02 | — | — | US | disclosed |
| EP-2334343-A1 | BIODEGRADABLE PROLINE-BASED POLYMERS | Medivas, LLC (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010045241-A1 | BIODEGRADABLE PROLINE-BASED POLYMERS | MEDIVAS, LLC (US) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120027859-A1 | Biodegradable Proline-Based Polymers | EPRS1, PRAP1, NPEPPS | PRCP 1144/4885MEN1 4399/4885KMT2A 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.