Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241360 | 0.82 | CYP1A2 (0.48) | NOTUMAKR1B1TDP1CYP1A2CYP2A6 | |
| SCHEMBL5233214 | 0.82 | CYP1A2 (0.48) | NOTUMTDP1CYP1A2POLBMAPT | |
| SCHEMBL5237113 | 0.76 | KMT2A (0.41) | TDP1POLBMAPTKMT2AMEN1 | |
| SCHEMBL23365341 | 0.76 | TDP1 (0.36) | TDP1POLBMAPTKMT2AMEN1 | |
| SCHEMBL8984622 | 0.76 | PNMT (0.54) | AKR1B1POLBTSHRKMT2AMEN1 | |
| SCHEMBL6046939 | 0.74 | KMT2A (0.57) | TDP1CYP1A2POLBMAPTTSHR | |
| SCHEMBL265672 | 0.74 | CTBP2 (0.55) | MAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL5237581 | 0.73 | HSP90AA1 (0.38) | NOTUMTDP1POLBMAPTKMT2A | |
| SCHEMBL25139447 | 0.72 | GPR84 (0.63) | TDP1POLBMAPTKMT2AMEN1 | |
| SCHEMBL14691047 | 0.71 | P2RX7 (0.45) | NOTUMAKR1B1L3MBTL1AKR1B10UGT1A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851232-A2 | DIHYDROIMIDAZOTHIAZOLE DERIVATIVES | Prosidion Limited (GB) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006085118-A2 | DIHYDROIMIDAZOTHIAZOLE DERIVATIVES | PROSIDION LIMITED (GB) | 2006-08-17 | — | — | WO | disclosed |