Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 14/20 | 0.38 |
| ▸ | DRD2 | P14416 | 14/20 | 0.38 |
| ▸ | HTR7 | P34969 | 9/20 | 0.38 |
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD5 | P21918 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235916 | 0.87 | AR (0.40) | — | |
| SCHEMBL5236555 | 0.84 | USP2 (0.41) | DRD3 | |
| SCHEMBL5238192 | 0.84 | CYP2C19 (0.37) | — | |
| SCHEMBL5234068 | 0.84 | DRD2 (0.45) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL5237575 | 0.83 | RBP4 (0.43) | DRD3 | |
| SCHEMBL5238831 | 0.83 | ALDH1A1 (0.43) | — | |
| SCHEMBL5239721 | 0.82 | TSHR (0.41) | HTR1ADRD2DRD4ADRA1ADRD3 | |
| SCHEMBL5239767 | 0.79 | ADRA1A (0.40) | DRD2ADRA1A | |
| SCHEMBL5235197 | 0.78 | HSD17B10 (0.45) | HTR1A | |
| SCHEMBL5236651 | 0.78 | HTT (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |