SCHEMBL5235945

SCHEMBL5235945

O=C(O)N1CCN(c2ccc(-c3ccc(Cl)cc3)cn2)CC1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 8/20 0.57
EGLN1 Q9GZT9 1/20 0.52
CNR2 P34972 3/20 0.51
ME2 P23368 2/20 0.51
ME1 P48163 2/20 0.51
ME3 Q16798 2/20 0.51
SLC6A7 Q99884 2/20 0.48
PANK3 Q9H999 1/20 0.47
ADK P55263 1/20 0.47
RAB9A P51151 1/20 0.46
ALDH1A1 P00352 1/20 0.45
MAPK1 P28482 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5237235 0.95 MGLL (0.53) MGLLEGLN1CNR2ME2ME1
SCHEMBL31589359 0.89 MGLL (0.53) MGLLEGLN1CNR2ME2ME1
SCHEMBL3442393 0.88 MGLL (0.58) MGLLCNR2ME2ME1ME3
SCHEMBL16397570 0.88 PANK3 (0.57) CNR2ME2ME1ME3PANK3
SCHEMBL31589397 0.86 HTR1A (0.52) MGLLME2ME1ME3SLC6A7
SCHEMBL5236075 0.85 CNR2 (0.54) MGLLCNR2ME2ME1ME3
SCHEMBL31589932 0.85 CNR2 (0.64) MGLLCNR2
SCHEMBL31589940 0.84 MGLL (0.63) MGLLCNR2
SCHEMBL31589999 0.83 MGLL (0.63) MGLLCNR2ME2ME1ME3
SCHEMBL5233345 0.82 CNR2 (0.51) MGLLCNR2RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1701946-B1 DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME SANOFI AVENTIS (FR) 2007-12-19 EP claimed
WO-2025108106-A1 COMPOUND CONTAINING QUINOLINONE SKELETON AND USE THEREOF 中国药科大学 2025-05-30 WO disclosed
CN-120040416-A Piperazine amide skeleton compound and application thereof 中国药科大学 2025-05-27 CN disclosed
CN-120040415-A Compound containing quinolinone skeleton and application thereof 中国药科大学 2025-05-27 CN disclosed