Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20419340 | 0.83 | GAA (0.59) | ALDH1A1TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3904994 | 0.83 | KMT2A (0.68) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL11508466 | 0.80 | SLC6A2 (0.72) | ALDH1A1TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27999926 | 0.79 | GAA (0.47) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL11498523 | 0.78 | SLC6A2 (0.70) | ALDH1A1TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3093835 | 0.78 | TSHR (0.76) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL5236897 | 0.77 | ALDH1A1 (0.53) | ALDH1A1TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5240191 | 0.76 | L3MBTL1 (0.49) | TSHRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL27671029 | 0.76 | L3MBTL1 (0.47) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL546735 | 0.76 | HTR1A (1.00) | SLC6A2SLC6A4SLC6A3HTR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |