Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239273 | 0.87 | ALDH1A1 (0.60) | ALDH1A1TSHRMEN1KMT2ALMNA | |
| SCHEMBL5235199 | 0.82 | GAA (0.53) | ALDH1A1TSHRGAASMN1; SMN2NPSR1 | |
| SCHEMBL5232433 | 0.82 | ALDH1A1 (0.59) | ALDH1A1TSHRGAASMN1; SMN2NPSR1 | |
| SCHEMBL5233076 | 0.81 | GAA (0.50) | ALDH1A1GAASMN1; SMN2MAPTMEN1 | |
| SCHEMBL5234580 | 0.81 | GAA (0.46) | ALDH1A1TSHRGAASMN1; SMN2CYP1A2 | |
| SCHEMBL5237576 | 0.81 | KMT2A (0.53) | ALDH1A1TSHRGAASMN1; SMN2NPSR1 | |
| SCHEMBL5239407 | 0.80 | MAPT (0.52) | ALDH1A1TSHRGAASMN1; SMN2NPSR1 | |
| SCHEMBL5235922 | 0.79 | HTR1A (0.51) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL5237366 | 0.78 | AKR1C3 (0.52) | ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL5234799 | 0.78 | MAPT (0.74) | ALDH1A1TSHRGAASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |