Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 2/20 | 0.56 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238733 | 0.89 | SMN1; SMN2 (0.64) | SMN1; SMN2HPGDMGLLSLC6A7IDE | |
| SCHEMBL593921 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2HPGDMGLLSLC6A7IDE | |
| SCHEMBL593375 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDMGLLSLC6A7IDE | |
| SCHEMBL5236004 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2HPGDMGLLSLC6A7IDE | |
| SCHEMBL5232330 | 0.82 | MGLL (0.64) | SMN1; SMN2HPGDMGLLSLC6A7IDE | |
| SCHEMBL594736 | 0.82 | LMNA (0.50) | SMN1; SMN2HPGDSLC6A7LMNAMAPK1 | |
| SCHEMBL5231536 | 0.79 | LMNA (0.70) | SMN1; SMN2LMNAMAPK1RAB9AALDH1A1 | |
| SCHEMBL5237745 | 0.79 | MGLL (0.60) | SMN1; SMN2MGLLSLC6A7LMNARAB9A | |
| SCHEMBL9401009 | 0.77 | ALDH1A1 (0.59) | SMN1; SMN2HPGDSLC6A7LMNAMAPK1 | |
| SCHEMBL593524 | 0.77 | SMN1; SMN2 (0.73) | SMN1; SMN2HPGDMGLLIDELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |