Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 7/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239397 | 0.81 | CNR2 (0.50) | CYP1A2KDRLOXL2 | |
| SCHEMBL5233508 | 0.81 | CNR2 (0.53) | VNN1CYP1A2KDR | |
| SCHEMBL5237313 | 0.79 | RAB9A (0.56) | CYP1A2LOXL2 | |
| SCHEMBL5231753 | 0.79 | CYP1A2 (0.53) | CYP1A2GRM4LOXL2AR | |
| SCHEMBL5235487 | 0.79 | CYP1A2 (0.44) | VNN1CYP1A2RIPK1KDRLOXL2 | |
| SCHEMBL5235891 | 0.77 | CYP1A2 (0.45) | CYP1A2KDRLOXL2GPBAR1RPS6KB1 | |
| SCHEMBL5233678 | 0.77 | RAB9A (0.56) | CYP1A2KDRLOXL2 | |
| SCHEMBL5238619 | 0.76 | KDR (0.35) | VNN1CYP1A2KDRAR | |
| SCHEMBL5234876 | 0.76 | CYP1A2 (0.49) | CYP1A2KDRLOXL2 | |
| SCHEMBL5239658 | 0.76 | CYP1A2 (0.61) | CYP1A2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |