Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236808 | 0.78 | CYP1A2 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20551403 | 0.76 | CES2 (0.40) | ALDH1A1CYP2C9 | |
| SCHEMBL166430 | 0.76 | CES2 (0.40) | ALDH1A1CYP2C9 | |
| SCHEMBL5949775 | 0.74 | IMPDH2 (0.45) | ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL845776 | 0.73 | ALDH1A1 (0.61) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5949824 | 0.72 | PARP1 (0.39) | ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20551784 | 0.71 | — | — | |
| SCHEMBL20551400 | 0.70 | MDM2 (0.38) | — | |
| SCHEMBL5236200 | 0.70 | CYP1A2 (0.48) | ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12463310 | 0.70 | HTR2B (0.42) | ALDH1A1TSHRCYP1A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851232-A2 | DIHYDROIMIDAZOTHIAZOLE DERIVATIVES | Prosidion Limited (GB) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006085118-A2 | DIHYDROIMIDAZOTHIAZOLE DERIVATIVES | PROSIDION LIMITED (GB) | 2006-08-17 | — | — | WO | disclosed |
| EP-1648876-A1 | 5-HT SB 2B /SB RECEPTOR ANTAGONISTS | Pharmagene Laboratories Ltd (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012263-A1 | 5-HT2B RECEPTOR ANTAGONISTS | PHARMAGENE LABORATORIES LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |