SCHEMBL524229

SCHEMBL524229

Nc1nc(O)nc2nc(O)[nH]c12

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.33
ADORA2A P29274 2/20 0.33
ADORA2B P29275 2/20 0.33
ADORA1 P30542 2/20 0.33
PNP P00491 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29394441 1.00 ADORA3 (0.33) ADORA3ADORA2AADORA2BADORA1PNP
SCHEMBL4907123 0.83 PDPK1 (0.44)
Water SCHEMBL8757461 0.81 PDPK1 (0.42)
Uric Acid SCHEMBL3325279 0.77
SCHEMBL27734016 0.72 ADORA3 (0.35) ADORA3ADORA2AADORA2BADORA1
SCHEMBL29454410 0.71 ADORA2A (0.61) ADORA2AADORA1
SCHEMBL42335 0.71 ADORA2A (0.61) ADORA2AADORA1
SCHEMBL6481197 0.70 NUDT1 (0.35) PNP
SCHEMBL29157618 0.68 PI4KA (0.37)
SCHEMBL8048768 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 869 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4681774-A2 KHK INHIBITORS Gilead Sciences, Inc. (US) 2026-01-21 EP claimed
EP-4313967-B1 KHK INHIBITORS GILEAD SCIENCES INC (US) 2025-11-12 EP claimed
EP-4313967-A1 KHK INHIBITORS GILEAD SCIENCES, INC. (US) 2024-02-07 EP claimed
US-20230416361-A1 ENGINEERED CD200R ANTIBODIES AND USES THEREOF OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2023-12-28 US claimed
CN-117120429-A KHK inhibitor 吉利德科学公司 2023-11-24 CN claimed
WO-2023196866-A1 ENGINEERED CD200R ANTIBODIES AND USES THEREOF MIROBIO LIMITED (GB) 2023-10-12 WO claimed
US-20230079863-A1 KHK INHIBITORS GILEAD SCIENCES, INC. 2023-03-16 US claimed
WO-2022212194-A1 KHK INHIBITORS GILEAD SCIENCES, INC. (US) 2022-10-06 WO claimed
EP-3519558-A1 USE OF ENGINEERED RENAL TISSUES IN ASSAYS Organovo, Inc. (US) 2019-08-07 EP claimed
WO-2018064323-A1 USE OF ENGINEERED RENAL TISSUES IN ASSAYS ORGANOVO, INC. (US) 2018-04-05 WO claimed
WO-2009127230-A1 MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION CUREVAC GMBH (DE) 2009-10-22 WO claimed
JP-3065650-A None JP disclosed
US-12622876-B2 Methods of suppressing delivery of exosomes to liver and spleen LONZA SALES AG (CH) 2026-05-12 US disclosed
US-20260092053-A1 KHK INHIBITORS GILEAD SCIENCES INC (US) 2026-04-02 US disclosed
EP-4705318-A2 KIDNEY-TARGETING AAV CAPSIDS AND METHODS OF USE THEREOF Oregon Health & Science University (US) 2026-03-11 EP disclosed
JP-H0365650-A METHOD OF MEASURING DIHYDROXYADENINE FUJIREBIO INC 1991-03-20 JP disclosed
EP-0034038-B1 USE OF SILVER HALIDE DEVELOPMENT ACCELERATORS, PHOTOGRAPHIC FILMS AND PROCESSES FOR DEVELOPING LITHOGRAFIC FILM E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-05-30 EP disclosed
US-4292391-A PYRAZOLO/3,4-D/PYRIMIDINES; PHOTOLITHOGRAPHY E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-29 US disclosed
EP-0034038-A1 Use of silver halide development accelerators, photographic films and processes for developing lithografic film E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-08-19 EP disclosed
JP-H00365650-A 0001-01-01 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092053-A1 KHK INHIBITORS KHK, SLC5A2, HK1 ADORA3 3619/4885ADORA2A 3124/4885ADORA2B 2845/4885
US-20230079863-A1 KHK INHIBITORS KHK, KHDRBS1, NADK ADORA3 4579/4885ADORA2A 4220/4885ADORA2B 4411/4885
US-12622876-B2 Methods of suppressing delivery of exosomes to liver and spleen EXOSC10, EXOSC5, EXOSC4 ADORA3 2468/4885ADORA2A 1799/4885ADORA2B 567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.