Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210487 | 0.86 | CHEK1 (0.57) | CHEK1MCHR1JAK2JAK3KCNH2 | |
| SCHEMBL2934362 | 0.85 | CHEK1 (0.58) | CHEK1JAK2JAK3KCNH2TBK1 | |
| SCHEMBL2933735 | 0.83 | CHEK1 (0.44) | CHEK1JAK2JAK3KCNH2 | |
| SCHEMBL2928252 | 0.83 | CHEK1 (0.42) | CHEK1JAK2JAK3KCNH2IKBKE | |
| SCHEMBL2932197 | 0.82 | CHEK1 (0.48) | CHEK1JAK2JAK3KCNH2FAAH | |
| SCHEMBL2925535 | 0.81 | JAK2 (0.43) | CHEK1JAK2JAK3KCNH2TBK1 | |
| SCHEMBL2931062 | 0.81 | CHEK1 (0.59) | CHEK1JAK2JAK3KCNH2TBK1 | |
| SCHEMBL2932975 | 0.79 | PTGER1 (0.43) | CHEK1JAK2JAK3KCNH2 | |
| SCHEMBL2930060 | 0.76 | CHEK1 (0.70) | CHEK1JAK2TBK1 | |
| SCHEMBL2927139 | 0.76 | CHEK1 (0.41) | CHEK1JAK2JAK3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421079-B1 | THIOPHENYL COMPOUNDS AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2007-02-07 | — | — | EP | claimed |