Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 7/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934362 | 0.86 | CHEK1 (0.58) | JAK2KCNH2JAK3CHEK1HIF1A | |
| SCHEMBL1928801 | 0.85 | CHEK1 (0.59) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL2931062 | 0.83 | CHEK1 (0.59) | JAK2KCNH2JAK3CHEK1TBK1 | |
| SCHEMBL2928252 | 0.82 | CHEK1 (0.42) | JAK2KCNH2JAK3CHEK1IKBKE | |
| SCHEMBL2933735 | 0.82 | CHEK1 (0.44) | JAK2KCNH2JAK3CHEK1 | |
| SCHEMBL2932197 | 0.82 | CHEK1 (0.48) | JAK2KCNH2JAK3CHEK1ABL1 | |
| SCHEMBL5243288 | 0.81 | CHEK1 (0.41) | JAK2KCNH2JAK3CHEK1TBK1 | |
| SCHEMBL2932975 | 0.81 | PTGER1 (0.43) | JAK2KCNH2JAK3CHEK1HIF1A | |
| SCHEMBL2930060 | 0.77 | CHEK1 (0.70) | JAK2CHEK1TBK1 | |
| SCHEMBL2933445 | 0.76 | CHEK1 (0.72) | CHEK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |