Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD2 | O14939 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HLA-A | P04439 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248338 | 0.87 | HSD17B10 (0.52) | SLC6A9OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5245812 | 0.82 | PLD1 (0.60) | PLD2SLC6A9OPRM1OPRL1OPRD1 | |
| SCHEMBL5245571 | 0.81 | OPRK1 (0.54) | SLC6A9OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL22587764 | 0.80 | PLD2 (0.62) | PLD2SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL5553371 | 0.79 | CYP3A4 (0.61) | PLD2SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL5243790 | 0.77 | CCR5 (0.57) | SLC6A9OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL10311318 | 0.77 | PLD2 (1.00) | PLD2CYP3A4CYP2D6PLD1 | |
| SCHEMBL5557913 | 0.76 | PLD2 (0.55) | PLD2SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL318707 | 0.75 | HSD17B10 (0.65) | SLC6A9OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL21634315 | 0.74 | HSD17B10 (0.60) | SLC6A9OPRM1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537110-B1 | TRIAZOSPIRO COMPOUNDS HAVING NOCICEPTIN RECEPTOR AFFINITY | EURO CELTIQUE SA (LU) | 2007-01-17 | — | — | EP | claimed |