Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 9/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248338 | 0.84 | HSD17B10 (0.52) | OPRK1SLC6A3HTR1AHTR2COPRM1 | |
| SCHEMBL5245812 | 0.81 | PLD1 (0.60) | OPRK1SLC6A3HTR1AADORA3HTR2C | |
| SCHEMBL5244755 | 0.81 | PLD2 (0.62) | OPRK1SLC6A3HTR1AHTR2COPRM1 | |
| SCHEMBL5243790 | 0.78 | CCR5 (0.57) | OPRK1SLC6A3HTR1AADORA3HTR2C | |
| SCHEMBL318707 | 0.72 | HSD17B10 (0.65) | OPRK1HTR2COPRM1OPRL1OPRD1 | |
| SCHEMBL13913516 | 0.72 | OPRM1 (0.67) | OPRK1SLC6A3HTR1AOPRM1OPRL1 | |
| SCHEMBL21634315 | 0.71 | HSD17B10 (0.60) | OPRK1HTR2COPRM1OPRL1OPRD1 | |
| SCHEMBL5925355 | 0.71 | OPRL1 (0.69) | OPRK1SLC6A3HTR1AOPRM1OPRL1 | |
| SCHEMBL318264 | 0.71 | OPRK1 (0.72) | OPRK1SLC6A3HTR1AADORA3HTR2C | |
| SCHEMBL21634299 | 0.70 | HSD17B10 (0.62) | OPRK1HTR2COPRM1OPRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537110-B1 | TRIAZOSPIRO COMPOUNDS HAVING NOCICEPTIN RECEPTOR AFFINITY | EURO CELTIQUE SA (LU) | 2007-01-17 | — | — | EP | claimed |