Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544423 | 0.82 | ALDH1A1 (0.43) | CYP2D6CYP2C9CYP2C19MAPK14ALDH1A1 | |
| SCHEMBL7086564 | 0.77 | CYP2C9 (0.60) | CYP2D6SMN1; SMN2CYP2C9CYP2C19MAPK14 | |
| SCHEMBL3544684 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2ACCR3HPGD | |
| SCHEMBL27943924 | 0.76 | CYP2C9 (0.55) | CYP2D6SMN1; SMN2CYP2C9CYP2C19MAPK14 | |
| SCHEMBL27597066 | 0.74 | CYP2C9 (0.50) | CYP2D6CYP2C9CYP2C19MAPK14MEN1 | |
| SCHEMBL14047747 | 0.74 | HRH3 (0.53) | CYP2D6ALDH1A1MEN1KMT2AHTR1A | |
| SCHEMBL23886286 | 0.74 | CYP2D6 (0.53) | CYP2D6ALDH1A1HTR1ASLC6A4 | |
| SCHEMBL23119230 | 0.72 | KDM4E (0.55) | CYP2C9CYP2C19MAPK14ALDH1A1MEN1 | |
| Acetic Acid SCHEMBL11160294 | 0.72 | SMN1; SMN2 (0.53) | CYP2D6SMN1; SMN2CYP2C9CYP2C19MAPK14 | |
| SCHEMBL7081823 | 0.72 | MEN1 (0.46) | SMN1; SMN2CYP2C9CYP2C19MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778675-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | Cylene Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015150-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | CYLENE PHARMACEUTICALS (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060025468-A1 | Chiral pyrrolidine derivatives, and methods for preparing compounds thereof | CYLENE PHARMACEUTICALS | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025468-A1 | Chiral pyrrolidine derivatives, and methods for preparing compounds thereof | PIN1, HPD, DHPS | CYP2D6 133/4885SMN1; SMN2 4589/4885CYP2C9 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.