⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141473 | 0.75 | ALDH1A1 (0.50) | — | |
| SCHEMBL11248848 | 0.73 | ALDH1A1 (0.48) | — | |
| SCHEMBL17333552 | 0.73 | — | — | |
| SCHEMBL5827132 | 0.71 | — | — | |
| SCHEMBL9179785 | 0.71 | ALDH1A1 (0.33) | — | |
| SCHEMBL5969873 | 0.71 | — | — | |
| SCHEMBL93503 | 0.71 | — | — | |
| SCHEMBL5827133 | 0.71 | BTN3A1 (0.35) | — | |
| SCHEMBL10687304 | 0.71 | PKM (0.40) | — | |
| SCHEMBL11107685 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11925690-B2 | Bifunctional molecules for targeting Rpn11 | AMPHISTA THERAPEUTICS LIMITED (GB) | 2024-03-12 | — | — | US | disclosed |
| EP-3807272-A1 | BIFUNCTIONAL MOLECULES FOR TARGETING RPN11 | Amphista Therapeutics Ltd (GB) | 2021-04-21 | — | — | EP | disclosed |
| EP-3807263-A1 | BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5 | Amphista Therapeutics Ltd (GB) | 2021-04-21 | — | — | EP | disclosed |
| WO-2019238816-A1 | BIFUNCTIONAL MOLECULES FOR TARGETING UCHL5 | UNIVERSITY OF DUNDEE (GB) | 2019-12-19 | — | — | WO | disclosed |
| WO-2019238886-A1 | BIFUNCTIONAL MOLECULES FOR TARGETING USP14 | UNIVERSITY OF DUNDEE (GB) | 2019-12-19 | — | — | WO | disclosed |
| WO-2019238817-A1 | BIFUNCTIONAL MOLECULES FOR TARGETING RPN11 | UNIVERSITY OF DUNDEE (GB) | 2019-12-19 | — | — | WO | disclosed |
| EP-1827605-B1 | PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING SOME INTERMEDIATES, AND THEIR USE AS ANTICANCER AGENTS | TELIK INC (US) | 2014-03-26 | — | — | EP | disclosed |
| US-8334266-B2 | Process for and intermediates in the preparation of canfosfamide and its salts | TELIK, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| US-20120238772-A1 | PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS | TELIK, INC. | 2012-09-20 | — | — | US | disclosed |
| US-8198247-B2 | Process for and intermediates in the preparation of canfosfamide and its salts | TELIK, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| EP-1827605-A1 | PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING SOME INTERMEDIATES, AND THEIR USE AS ANTICANCER AGENTS | TELIK, INC. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006068769-A1 | PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING SOME INTERMEDIATES, AND THEIR USE AS ANTICANCER AGENTS | TELIK, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
| US-20060135409-A1 | Process for and intermediates in the preparation of canfosfamide and its salts | TELIK, INC. | 2006-06-22 | — | — | US | disclosed |
| US-4517002-A | Phosphorodiamide urease inhibitors and urease inhibited urea based fertilizer compositions | ALLIED CORPORATION (US) | 1985-05-14 | — | — | US | disclosed |
| EP-0119494-A1 | Urease inhibited urea based fertilizer compositions containing phosphorus compounds | ALLIED CORPORATION (US) | 1984-09-26 | — | — | EP | disclosed |