Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596391 | 0.85 | KMT2A (0.41) | KMT2AALDH1A1NPC1MAPTMEN1 | |
| SCHEMBL13993462 | 0.84 | THRB (0.41) | KMT2AALDH1A1NPC1MAPTRORC | |
| SCHEMBL13544245 | 0.84 | HSD17B10 (0.51) | KMT2AHSD17B10ALDH1A1NPC1MAPT | |
| SCHEMBL13544272 | 0.79 | RAF1 (0.40) | KMT2AALDH1A1NPC1MAPTSMN1; SMN2 | |
| SCHEMBL3592435 | 0.78 | TRPV1 (0.49) | KMT2AALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL13544243 | 0.77 | PTGES (0.51) | KMT2AHSD17B10ALDH1A1NPC1RORC | |
| SCHEMBL3579041 | 0.74 | NR3C1 (0.40) | KMT2ANPC1RAB9APARP1 | |
| SCHEMBL13544252 | 0.72 | PKM (0.48) | KMT2AHSD17B10ALDH1A1NPC1RORC | |
| SCHEMBL3583759 | 0.72 | TRPV1 (0.48) | CNR1 | |
| SCHEMBL13544762 | 0.68 | KMT2A (0.51) | KMT2AALDH1A1NPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853269-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2007-11-14 | — | — | EP | claimed |
| WO-2006093832-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2006-09-08 | — | — | WO | claimed |