SCHEMBL5248151

SCHEMBL5248151

Nc1ccc(Oc2ccc(CNC(=O)N3CCN(Cc4ccc5c(c4)OCO5)CC3)cc2)nc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 8/20 0.53
LMNA P02545 4/20 0.51
GAA P10253 1/20 0.51
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP3A4 P08684 2/20 0.50
MAPT P10636 2/20 0.50
MCHR1 Q99705 1/20 0.50
TSHR P16473 1/20 0.50
ABCB11 O95342 1/20 0.50
CYP1A2 P05177 1/20 0.50
ADRA2A P08913 1/20 0.50
CYP2D6 P10635 1/20 0.50
CHRM1 P11229 1/20 0.50
TBXA2R P21731 1/20 0.50
SLC6A2 P23975 1/20 0.50
SLC6A4 P31645 1/20 0.50
CYP2C19 P33261 1/20 0.50
ADRA1A P35348 1/20 0.50
OPRM1 P35372 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3142160 0.85 LMNA (0.55) LMNAMEN1KMT2ACYP3A4MAPT
Hydrochloric Acid SCHEMBL3134931 0.85 CYP3A4 (0.56) LMNAMEN1KMT2ACYP3A4MAPT
Hydrochloric Acid SCHEMBL3267187 0.81 MEN1 (0.53) FAAHLMNAGAAMEN1KMT2A
SCHEMBL3139361 0.81 KDM4E (0.50) FAAHLMNAMEN1KMT2ACYP3A4
SCHEMBL3135139 0.80 ALDH1A1 (0.60) LMNAMEN1KMT2APOLBHTT
SCHEMBL4761617 0.79 LMNA (0.54) FAAHLMNAMEN1KMT2ACYP3A4
SCHEMBL3138325 0.79 KMT2A (0.56) FAAHLMNAMEN1KMT2ACYP3A4
SCHEMBL3058663 0.79 MAPT (0.49) LMNAMEN1KMT2ACYP3A4MAPT
SCHEMBL3057094 0.79 HPGD (0.53) LMNAMEN1KMT2ACYP3A4MAPT
SCHEMBL3139016 0.79 FAAH (0.64) FAAHLMNAGAAMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120238750-A1 AROMATIC COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. 2012-09-20 US disclosed
US-8188277-B2 Aromatic compounds for suppressing the generation of collagen OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2012-05-29 US disclosed
US-20070270422-A1 Aromatic Compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-11-22 US disclosed
EP-1773797-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-04-18 EP disclosed
WO-2006014012-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-02-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120238750-A1 AROMATIC COMPOUND CBR1, CBR3, CYP1A1 FAAH 2018/4885LMNA 2721/4885GAA 4225/4885
US-20070270422-A1 Aromatic Compounds COL1A1, COL2A1, COL14A1 FAAH 2289/4885LMNA 1091/4885GAA 3249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.