Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252071 | 0.83 | BCHE (0.43) | TYMSALDH1A1ALOX5MAPTKMT2A | |
| SCHEMBL5253913 | 0.81 | TYMS (0.41) | TYMSALDH1A1ALOX5GLACTDSP1 | |
| SCHEMBL4840445 | 0.73 | MAPT (0.44) | ALDH1A1GLACTDSP1MAPTKMT2A | |
| SCHEMBL6204224 | 0.69 | TYMS (0.37) | TYMSALDH1A1ALOX5GLACTDSP1 | |
| SCHEMBL4843861 | 0.68 | ALDH1A1 (0.43) | ALDH1A1GLACTDSP1MAPTKMT2A | |
| SCHEMBL1960366 | 0.66 | TYMS (0.51) | TYMSALDH1A1GLAMAPTKMT2A | |
| SCHEMBL37520 | 0.65 | MAPT (0.56) | ALDH1A1ALOX5MAPTKMT2AMEN1 | |
| SCHEMBL1839147 | 0.64 | L3MBTL1 (0.49) | TYMSALDH1A1ALOX5TDP1KDM4E | |
| SCHEMBL8526462 | 0.64 | ALDH1A1 (0.44) | TYMSALDH1A1ALOX5KMT2AMEN1 | |
| SCHEMBL17697666 | 0.64 | LMNA (0.47) | TYMSALDH1A1ALOX5MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684702-B1 | USE OF 2-THIA-DIBENZO[E,H]AZULENES FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | GLAXOSMITHKLINE ZAGREB (HR) | 2007-09-19 | — | — | EP | claimed |
| EP-1509530-B1 | 2-THIA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA ISTRAZIVACKI INST D O O (HR) | 2006-03-15 | — | — | EP | claimed |