SCHEMBL5249351

SCHEMBL5249351

CC#Cc1ccccc1Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.42
CALM1 P0DP23 1/20 0.42
BCL2 P10415 1/20 0.41
BCL2L1 Q07817 1/20 0.41
HRH1 P35367 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
DRD2 P14416 1/20 0.38
DRD1 P21728 1/20 0.38
DRD4 P21917 1/20 0.38
DRD5 P21918 1/20 0.38
CYP1A2 P05177 2/20 0.37
TP53 P04637 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
TSHR P16473 1/20 0.37
FFAR1 O14842 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1B1 Q16678 1/20 0.36
ALOX5 P09917 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9569110 0.80 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1L3MBTL1
SCHEMBL24612515 0.78 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1L3MBTL1
SCHEMBL23704288 0.77 FFAR1 (0.46) L3MBTL1CYP1A2TP53CYP3A4CYP2C9
SCHEMBL4599195 0.75 L3MBTL1 (0.39) HTR2ACALM1BCL2BCL2L1L3MBTL1
SCHEMBL2870972 0.75 CALM1 (0.46) HTR2ACALM1BCL2BCL2L1HRH1
SCHEMBL722161 0.75 CALM1 (0.46) HTR2ACALM1BCL2BCL2L1L3MBTL1
SCHEMBL1252940 0.75 TSHR (0.48) HTR2ACALM1BCL2BCL2L1TSHR
SCHEMBL6364807 0.72 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C9TSHRCYP1A1
SCHEMBL972711 0.72 CALM1 (0.69) HTR2ACALM1BCL2BCL2L1HRH1
SCHEMBL8130887 0.72 GABRA1 (0.45) CYP1A2FFAR1CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476438-B1 OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS VERNALIS R&D LTD (GB) 2007-04-18 EP claimed