Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | LIPA | P38571 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320124 | 0.82 | ALDH1A1 (0.48) | ALDH1A1POLBGAASMN1; SMN2HSD11B1 | |
| SCHEMBL6120 | 0.71 | USP2 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL3554732 | 0.70 | ALDH1A1 (0.62) | ALDH1A1POLBSMN1; SMN2HSD11B1 | |
| SCHEMBL19066161 | 0.69 | CA2 (0.55) | ALDH1A1POLBSMN1; SMN2HSD11B1 | |
| SCHEMBL2092626 | 0.69 | CYP2C9 (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL3031399 | 0.69 | ALDH1A1 (0.67) | ALDH1A1POLBSMN1; SMN2HSD11B1 | |
| SCHEMBL74877 | 0.68 | TSHR (0.57) | ALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL771109 | 0.68 | TPSAB1 (0.43) | — | |
| SCHEMBL6068458 | 0.67 | — | — | |
| SCHEMBL2097634 | 0.67 | TSHR (0.50) | ALDH1A1POLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-B1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LAB (US) | 2007-09-12 | — | — | EP | claimed |