Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495344 | 0.88 | TP53 (0.33) | MAPTGAAKDM4ETSHRHSD17B10 | |
| SCHEMBL9499230 | 0.84 | TSHR (0.39) | MAPTGAATSHRPARP1SMN1; SMN2 | |
| SCHEMBL9496918 | 0.82 | KMT2A (0.42) | TDP1POLBL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL5253142 | 0.81 | MEN1 (0.43) | MAPTKDM4ETSHRHSD17B10POLB | |
| SCHEMBL9498421 | 0.79 | — | — | |
| SCHEMBL9494438 | 0.79 | EPHX1 (0.40) | MAPTGAAKDM4EHSD17B10CYP3A4 | |
| SCHEMBL9494535 | 0.76 | KDM4E (0.31) | KDM4E | |
| SCHEMBL5252939 | 0.73 | RAB9A (0.45) | MAPTTSHRTDP1SMN1; SMN2NPC1 | |
| SCHEMBL9495288 | 0.73 | NPC1 (0.40) | GFERTSHRTDP1POLBSMN1; SMN2 | |
| SCHEMBL9494589 | 0.73 | NPC1 (0.45) | MAPTGAAKDM4ECYP3A4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1770093-A1 | Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors | Roche Palo Alto LLC (US) | 2007-04-04 | — | — | EP | disclosed |
| US-5264437-A | Antiinflammatory agents, immunosuppressants or antiallergens | SYNTEX (U.S.A.) INC. (US) | 1993-11-23 | — | — | US | disclosed |