Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290162 | 0.92 | CYP19A1 (0.57) | CYP19A1ALDH1A1SMN1; SMN2GPR119PIN1 | |
| SCHEMBL6655200 | 0.78 | GPR119 (0.54) | ALDH1A1SMN1; SMN2GPR119PIN1CYP1A2 | |
| SCHEMBL30242159 | 0.75 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19KDM4E | |
| SCHEMBL333768 | 0.75 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19KDM4E | |
| SCHEMBL7671126 | 0.74 | ALDH1A1 (0.49) | CYP19A1ALDH1A1SMN1; SMN2GRM5LMNA | |
| SCHEMBL3287938 | 0.73 | ALDH1A1 (0.62) | CYP19A1ALDH1A1SMN1; SMN2PIN1CYP1A2 | |
| SCHEMBL15831950 | 0.71 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GPR119PIN1CYP1A2 | |
| SCHEMBL15831940 | 0.71 | HDAC1 (0.48) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL23657921 | 0.69 | CFTR (0.50) | CYP19A1ALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL3290347 | 0.69 | LMNA (0.42) | CYP19A1ALDH1A1SMN1; SMN2GRM5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747206-A1 | AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005111003-A1 | AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |