Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664554 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TDP1LMNACYP19A1 | |
| SCHEMBL25101056 | 0.80 | CYP11B1 (0.47) | ALDH1A1SMN1; SMN2TDP1LMNACYP19A1 | |
| SCHEMBL7672764 | 0.75 | HTR2A (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5254356 | 0.74 | CYP19A1 (0.50) | ALDH1A1SMN1; SMN2TDP1LMNACYP19A1 | |
| SCHEMBL7667163 | 0.73 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNASYKHTT | |
| SCHEMBL7668427 | 0.73 | ADORA2A (0.42) | GRM5CHRNB2CHRNA4 | |
| SCHEMBL20176876 | 0.73 | LMNA (0.60) | ALDH1A1SMN1; SMN2TDP1LMNACYP19A1 | |
| SCHEMBL29972517 | 0.73 | LMNA (0.60) | ALDH1A1SMN1; SMN2TDP1LMNACYP19A1 | |
| SCHEMBL7667111 | 0.72 | HTR2A (0.43) | LMNAHTT | |
| SCHEMBL14022002 | 0.72 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2TDP1LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |
| US-6184237-B1 | Substituted pyridine compounds and methods of use | AMGEN INC. | 2001-02-06 | — | — | US | disclosed |