Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18900177 | 0.81 | LCK (0.57) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL3155647 | 0.80 | CTSD (0.59) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL11085362 | 0.79 | CTSD (0.57) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL14244867 | 0.78 | ABL1 (0.69) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL2945976 | 0.77 | MAPK14 (0.60) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL2945585 | 0.76 | MAPK14 (0.48) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL2955979 | 0.76 | TRPA1 (0.48) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL26154428 | 0.75 | CTSD (0.54) | TRPA1CTSDBACE1LCKKDR | |
| SCHEMBL14417256 | 0.74 | ESR2 (0.73) | TRPA1CTSDBACE1ABL1MCL1 | |
| SCHEMBL5362363 | 0.74 | ESR1 (0.52) | BACE1PGRCLK4ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094187-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2006-09-08 | — | — | WO | disclosed |