Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851131 | 0.70 | G6PD (0.65) | MYCL3MBTL1ALDH1A1MAPTG6PD | |
| SCHEMBL1739256 | 0.69 | MARS1 (0.53) | L3MBTL1ALDH1A1GAAKDM4EAURKA | |
| SCHEMBL5254258 | 0.69 | G6PD (0.44) | MYCL3MBTL1ALDH1A1MAPTG6PD | |
| SCHEMBL7851664 | 0.68 | MYC (0.73) | MYCL3MBTL1TDP1ALDH1A1MAPT | |
| SCHEMBL5324718 | 0.68 | NPC1 (0.56) | ALDH1A1MAPTGAAS1PR1KDM4E | |
| SCHEMBL5465583 | 0.68 | GAA (0.62) | TDP1ALDH1A1MAPTGAAUSP2 | |
| SCHEMBL1186870 | 0.67 | MYC (0.49) | MYCALDH1A1MAPTG6PDCASP7 | |
| SCHEMBL17744802 | 0.67 | G6PD (0.61) | MYCL3MBTL1ALDH1A1MAPTG6PD | |
| SCHEMBL23115771 | 0.67 | S1PR1 (0.45) | L3MBTL1TDP1ALDH1A1MAPTNPSR1 | |
| SCHEMBL8560028 | 0.67 | PIK3CG (0.49) | MYCALDH1A1MAPTKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807426-A2 | SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Cytovia, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006041900-A2 | SUBSTITUTED N-ARYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA, INC. (US) | 2006-04-20 | — | — | WO | disclosed |