Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 9/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259083 | 0.88 | POLB (0.41) | ACMSDKMOSTAT3POLB | |
| SCHEMBL5219458 | 0.86 | OPRK1 (0.34) | STAT3 | |
| SCHEMBL5219215 | 0.77 | KDM4E (0.31) | — | |
| SCHEMBL5218910 | 0.75 | MCL1 (0.34) | POLBDHODH | |
| SCHEMBL5221190 | 0.75 | CTSD (0.34) | POLB | |
| SCHEMBL5219461 | 0.75 | CTSD (0.36) | POLB | |
| SCHEMBL5220629 | 0.74 | BACE1 (0.43) | — | |
| SCHEMBL5222301 | 0.74 | POLB (0.43) | ACMSDKMOPOLB | |
| SCHEMBL5223783 | 0.73 | CTSD (0.30) | — | |
| SCHEMBL5222895 | 0.71 | MCL1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |