Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773151 | 0.79 | MEN1 (0.40) | KMT2AMEN1USP2PPARGKEAP1 | |
| SCHEMBL2552199 | 0.79 | MEN1 (0.40) | KMT2AMEN1USP2PPARGKEAP1 | |
| SCHEMBL1773148 | 0.79 | MEN1 (0.40) | KMT2AMEN1USP2PPARGKEAP1 | |
| Hydrochloric Acid SCHEMBL4845131 | 0.78 | MEN1 (0.37) | KMT2AMEN1USP2PPARGKEAP1 | |
| SCHEMBL309794 | 0.71 | MAPT (0.50) | KMT2AMEN1USP2PPARGKEAP1 | |
| SCHEMBL9232229 | 0.70 | TRPA1 (0.55) | KMT2AMEN1KEAP1HSD17B10SMN1; SMN2 | |
| SCHEMBL6029951 | 0.69 | HTR1A (0.44) | HSD17B10ALDH1A1KDM4ECYP3A4LMNA | |
| SCHEMBL1132587 | 0.69 | TRPA1 (0.40) | KMT2AMEN1USP2PPARGKEAP1 | |
| SCHEMBL3688075 | 0.68 | DRD2 (0.51) | KMT2AMEN1USP2HSD17B10SMN1; SMN2 | |
| SCHEMBL89481 | 0.68 | TRPA1 (0.55) | SMN1; SMN2CASP1CASP7CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865962-A2 | USE OF N-DESMETHYLCLOZAPINE AND RELATED COMPOUNDS AS DOPAMINE STABILIZING AGENTS | Arcadia Pharmaceuticals Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006107948-A9 | USE OF N-DESMETHYLCLOZAPINE AND RELATED COMPOUNDS AS DOPAMINE STABILIZING AGENTS | ACADIA PHARM INC (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2006107948-A2 | USE OF N-DESMETHYLCLOZAPINE AND RELATED COMPOUNDS AS DOPAMINE STABILIZING AGENTS | ACADIA PHARMACEUTICALS INC. (US) | 2006-10-12 | — | — | WO | disclosed |
| EP-1589974-A2 | USE OF N-DESMETHYLCLOZAPINE TO TREAT HUMAN NEUROPSYCHIATRIC DISEASE | Acadia Pharmaceuticals Inc. (US) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004064753-A2 | USE OF N-DESMETHYLCLOZAPINE TO TREAT HUMAN NEUROPSYCHIATRIC DISEASE | ACADIA PHARMACEUTICALS INC (US) | 2004-08-05 | — | — | WO | disclosed |