Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 8/20 | 0.42 |
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262912 | 0.80 | KDM4E (0.44) | MC4RSLC6A3MEN1KMT2A | |
| SCHEMBL19953550 | 0.79 | ADRA2C (0.47) | ADRA2CMC4RCCR3CHRM2CHRM4 | |
| SCHEMBL27915911 | 0.70 | ADRA2C (0.44) | ADRA2CMC4RCCR3CHRM1LMNA | |
| SCHEMBL30085024 | 0.69 | CYP1A2 (0.42) | CYP2D6SLC6A3KCNH2 | |
| SCHEMBL28582139 | 0.67 | CYP1A2 (0.60) | CYP2D6KCNH2MEN1KMT2AGAA | |
| SCHEMBL28425577 | 0.66 | LMNA (0.49) | ADRA2CMC4RCCR3CHRM2CHRM4 | |
| SCHEMBL25375773 | 0.65 | MC4R (0.62) | MC4RCCR3CHRM2CHRM4CHRM5 | |
| SCHEMBL2843665 | 0.65 | MC4R (0.62) | MC4RCCR3CHRM2CHRM4CHRM5 | |
| SCHEMBL4765378 | 0.65 | ADRA2C (0.41) | ADRA2CDRD1DRD3KCNH2HTR1D | |
| SCHEMBL15272244 | 0.65 | CPN1 (0.36) | ADRA2CCYP2D6KCNH2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773817-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012374-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-02-02 | — | — | WO | disclosed |