Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15272244 | 0.86 | CPN1 (0.36) | ADRA2CKCNH2CYP2D6ALDH1A1TSHR | |
| SCHEMBL3580010 | 0.82 | SLC6A3 (0.42) | CHRM2CHRM1ADRA2ADRD1DRD3 | |
| SCHEMBL3935389 | 0.81 | KDM4E (0.44) | ADRA2CCHRM2CHRM1ADRA2ADRD1 | |
| SCHEMBL13258519 | 0.81 | CHRM1 (0.59) | CHRM2CHRM1ADRA2ADRD1DRD3 | |
| SCHEMBL12066465 | 0.81 | CHRM1 (0.59) | CHRM2CHRM1ADRA2ADRD1DRD3 | |
| SCHEMBL5259902 | 0.79 | ADRA2C (0.44) | ADRA2CCHRM2CHRM1ADRA2ADRD1 | |
| SCHEMBL3585713 | 0.74 | LIPG (0.36) | CHRM2CHRM1ADRA2ADRD1DRD3 | |
| SCHEMBL27915911 | 0.73 | ADRA2C (0.44) | ADRA2CCHRM1MC4RCCR3 | |
| SCHEMBL15286386 | 0.72 | ALDH1A1 (0.41) | CHRM2CHRM1ADRA2ADRD1DRD3 | |
| SCHEMBL4765378 | 0.70 | ADRA2C (0.41) | ADRA2CDRD1DRD3KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510030-A1 | 8-(AZETIDIN-1-YL)-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | H. Hoffnabb-La Roche Ag (CH) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018046409-A1 | 8-(AZETIDIN-1-YL)-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-15 | — | — | WO | disclosed |