Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259902 | 0.80 | ADRA2C (0.44) | MC4RMEN1KMT2ASLC6A3 | |
| SCHEMBL21200200 | 0.74 | KMT2A (0.55) | ALDH1A1TDP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL21200199 | 0.74 | KMT2A (0.55) | ALDH1A1TDP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL28418775 | 0.71 | MC4R (0.55) | ALDH1A1MC4RMEN1KMT2AL3MBTL1 | |
| SCHEMBL22164017 | 0.70 | MC4R (0.47) | MC4RSLC6A2SLC6A3 | |
| SCHEMBL15272230 | 0.69 | LMNA (0.47) | KDM4EALDH1A1TDP1MAPTSMN1; SMN2 | |
| SCHEMBL9865491 | 0.68 | KMT2A (0.41) | KDM4EALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1203455 | 0.67 | SIRT6 (0.66) | KDM4EALDH1A1BCL2A1MAPTSMN1; SMN2 | |
| SCHEMBL30198400 | 0.67 | SIRT6 (0.66) | KDM4EALDH1A1BCL2A1MAPTSMN1; SMN2 | |
| SCHEMBL2716970 | 0.67 | ALDH1A1 (0.73) | KDM4EALDH1A1TDP1MC4RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773817-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012374-A1 | SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-02-02 | — | — | WO | disclosed |