Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5259008 | 0.84 | VNN1 (0.42) | MMP2MMP9MMP8MMP13HDAC6 | |
| Trifluoroacetic Acid SCHEMBL4834909 | 0.83 | HDAC6 (0.47) | CHEK2MMP2MMP9MMP8MMP13 | |
| Trifluoroacetic Acid SCHEMBL4842876 | 0.83 | CHEK2 (0.45) | CHEK2PARP1MMP2MMP9MMP8 | |
| Trifluoroacetic Acid SCHEMBL4842729 | 0.83 | AURKA (0.52) | CHEK2PARP1CCNB2CDK1CCNB1 | |
| Trifluoroacetic Acid SCHEMBL4838856 | 0.82 | TBK1 (0.43) | KCNH2 | |
| Trifluoroacetic Acid SCHEMBL5260040 | 0.82 | ALDH1A1 (0.48) | MMP2MMP9MMP8MMP13HDAC6 | |
| Trifluoroacetic Acid SCHEMBL4838225 | 0.80 | IKBKE (0.43) | DGAT1SOAT1KCNH2CHEK2PARP1 | |
| Trifluoroacetic Acid SCHEMBL4835232 | 0.80 | HDAC3 (0.50) | DGAT1CHEK2MMP2MMP9MMP8 | |
| Trifluoroacetic Acid SCHEMBL4838115 | 0.80 | DGAT1 (0.41) | DGAT1KCNH2CHEK2PARP1 | |
| Trifluoroacetic Acid SCHEMBL4834242 | 0.79 | HDAC6 (0.40) | CHEK2MMP2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | DGAT1 4827/4885SOAT1 1628/4885KCNH2 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.