Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263063 | 0.85 | RAB9A (0.65) | RAB9ANPC1KMT2AGAAMEN1 | |
| SCHEMBL5260117 | 0.81 | CNR1 (0.54) | RAB9ANPC1CNR1CNR2 | |
| SCHEMBL3237117 | 0.81 | NPC1 (0.56) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL4688879 | 0.80 | MAPT (0.43) | RAB9ANPC1ITGB3ITGB1ITGAV | |
| SCHEMBL5264039 | 0.79 | KMT2A (0.53) | RAB9ANPC1KMT2AGAAHSD17B10 | |
| SCHEMBL5259145 | 0.76 | ALDH1A1 (0.46) | RAB9ANPC1KMT2AGAAHSD17B10 | |
| SCHEMBL5262774 | 0.75 | SLC6A9 (0.54) | RAB9ANPC1KMT2AGAAHSD17B10 | |
| SCHEMBL5266049 | 0.73 | RAB9A (0.60) | RAB9ANPC1KMT2ATP53MEN1 | |
| SCHEMBL5263349 | 0.72 | MAPT (0.65) | RAB9ANPC1KMT2AHSD17B10MEN1 | |
| SCHEMBL5262488 | 0.71 | SLC6A9 (0.55) | RAB9ANPC1KMT2AMEN1CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |