Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263349 | 0.88 | MAPT (0.65) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5260346 | 0.85 | RAB9A (0.46) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL6327703 | 0.81 | RAB9A (0.63) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3230238 | 0.81 | NPC1 (0.80) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5264039 | 0.79 | KMT2A (0.53) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5259145 | 0.76 | ALDH1A1 (0.46) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5262774 | 0.75 | SLC6A9 (0.54) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL743304 | 0.74 | MEN1 (1.00) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5266049 | 0.73 | RAB9A (0.60) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5261535 | 0.73 | TP53 (0.56) | RAB9AKMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |