Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428078 | 0.83 | GRM5 (0.42) | HTR1AHTR1DSLC6A4KCNH2HTR1B | |
| SCHEMBL6518006 | 0.71 | HTR1A (0.51) | HTR1AHTR1DSLC6A4KCNH2ALDH1A1 | |
| SCHEMBL6065302 | 0.71 | CYP2C9 (0.51) | HTR1AHTR1DSLC6A4KCNH2ALDH1A1 | |
| SCHEMBL4178267 | 0.70 | GPR119 (0.50) | HTR1AHTR1DSLC6A4KCNH2GAA | |
| SCHEMBL13525142 | 0.68 | HTR1A (0.54) | HTR1AHTR1DSLC6A4KCNH2ALDH1A1 | |
| SCHEMBL8664465 | 0.67 | RAB9A (0.51) | TSHRALDH1A1GAARAB9A | |
| SCHEMBL425989 | 0.66 | PDK2 (0.42) | HTR1AHTR1DSLC6A4KCNH2ALDH1A1 | |
| SCHEMBL6065199 | 0.63 | MEN1 (0.42) | TSHRALDH1A1GAA | |
| SCHEMBL6186757 | 0.63 | GRM5 (0.47) | — | |
| SCHEMBL12270047 | 0.63 | RAB9A (0.68) | TSHRALDH1A1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |