SCHEMBL5260945

SCHEMBL5260945

COC(=O)C(=NO)c1ccccc1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
HPGD P15428 2/20 0.43
ERCC5 P28715 1/20 0.42
FEN1 P39748 1/20 0.42
KDM4E B2RXH2 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
LMNA P02545 1/20 0.41
KMT2A Q03164 3/20 0.40
POLB P06746 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MEN1 O00255 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
KCNK3 O14649 1/20 0.40
KCNK9 Q9NPC2 1/20 0.40
DHODH Q02127 1/20 0.40
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
ALOX12 P18054 1/20 0.39
TYK2 P29597 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20797805 1.00 NPC1 (0.44) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL28864438 0.86 NPC1 (0.44) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL28864439 0.86 NPC1 (0.44) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL29810082 0.84 HIF1A (0.51) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL6155893 0.84 HIF1A (0.51) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL29445316 0.84 HIF1A (0.51) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL29883529 0.84 HIF1A (0.51) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL7040691 0.84 HIF1A (0.51) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL3747106 0.84 HIF1A (0.51) NPC1RAB9AHPGDERCC5FEN1
SCHEMBL7124266 0.82 LMNA (0.56) NPC1HPGDKDM4ETDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3681863-B1 \"AN IMPROVED PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN\ HIKAL LTD (IN) 2024-07-17 EP disclosed
US-11649204-B2 Process for the preparation of trifloxystrobin HIKAL LIMITED (IN) 2023-05-16 US disclosed
US-20200283373-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN HIKAL LIMITED (IN) 2020-09-10 US disclosed
EP-3681863-A1 \"AN IMPROVED PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN\ Hikal Limited (IN) 2020-07-22 EP disclosed
WO-2019049167-A1 \"AN IMPROVED PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN\ HIKAL LIMITED (IN) 2019-03-14 WO disclosed
EP-0844993-B1 PESTICIDAL INDAZOLE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2007-09-26 EP disclosed
US-6670496-B1 Diazotizing aniline derivative and reacting with an oxime in presence of cupric salt to directly form E-isomers BAYER AKTIENGESELLSCHAFT (DE) 2003-12-30 US disclosed
EP-1173410-B1 PROCESS FOR THE PREPARATION OF PHENYL GLYOXYLIC ACID ESTER OXIMES BAYER CROPSCIENCE AG (DE) 2003-10-22 EP disclosed
EP-1173410-A1 PROCESS FOR THE PREPARATION OF PHENYL GLYOXYLIC ACID ESTER OXIMES Bayer Aktiengesellschaft (DE) 2002-01-23 EP disclosed
WO-2000063162-A1 PROCESS FOR THE PREPARATION OF PHENYL GLYOXYLIC ACID ESTER OXIMES BAYER AKTIENGESELLSCHAFT (DE) 2000-10-26 WO disclosed
US-5935908-A PLANT GROWTH REGULATOR NOVARTIS CROP PROTECTION, INC. (US) 1999-08-10 US disclosed
EP-0844993-A2 PESTICIDAL INDAZOLE DERIVATIVES Novartis AG (CH) 1998-06-03 EP disclosed
US-5710314-A FUNGICIDES OR INSECTICIDES OF AROMATIC ETHERS WITH ESTER GROUPS OR AMIDES NOVARTIS CORPORATION (US) 1998-01-20 US disclosed
EP-0777645-A1 OXIME ETHERS AND THEIR USE AS PESTICIDES Novartis AG (CH) 1997-06-11 EP disclosed
WO-1997007103-A2 PESTICIDAL INDAZOLE DERIVATIVES NOVARTIS AG (CH) 1997-02-27 WO disclosed
WO-1996006072-A1 OXIME ETHERS AND THEIR USE AS PESTICIDES CIBA-GEIGY AG (CH) 1996-02-29 WO disclosed
US-5145980-A OXIME ETHERS, AND FUNGICIDES CONTAINING SAME BASF AKTIENGESELLSCHAFT (DE) 1992-09-08 US disclosed
EP-0254426-B1 FUNGICIDES ZENECA LIMITED (GB) 1992-01-29 EP disclosed
EP-0400417-A1 Oximethers and fungicides containing them BASF Aktiengesellschaft (DE) 1990-12-05 EP disclosed
EP-0254426-A2 Fungicides ZENECA LIMITED (GB) 1988-01-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649204-B2 Process for the preparation of trifloxystrobin CYP3A7, CYP51A1, TREH NPC1 1815/4885RAB9A 3503/4885HPGD 3087/4885
US-20200283373-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF TRIFLOXYSTROBIN SI, TREH, CYP3A7 NPC1 1565/4885RAB9A 3284/4885HPGD 3913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.