SCHEMBL526097

SCHEMBL526097

O=Cc1ccc2c(c1)CCN2CCC(=O)OCc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.49
L3MBTL1 Q9Y468 3/20 0.46
MAPT P10636 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
KDM4E B2RXH2 1/20 0.46
POLB P06746 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
TMEM97 Q5BJF2 5/20 0.42
SIGMAR1 Q99720 5/20 0.42
SLC6A2 P23975 2/20 0.42
HRH2 P25021 2/20 0.42
HRH1 P35367 2/20 0.42
HTR1A P08908 1/20 0.42
CHRM5 P08912 1/20 0.42
ADRA1D P25100 1/20 0.42
HTR1B P28222 1/20 0.42
HTR2A P28223 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL526977 0.84 NOTUM (0.67) NOTUML3MBTL1MAPTMEN1KMT2A
SCHEMBL4537409 0.80 TEAD3 (0.43) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL8778013 0.78 MEN1 (0.47) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL3218987 0.77 HPGD (0.48) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL525875 0.77 MAPT (0.46) NOTUML3MBTL1MAPTMEN1KMT2A
SCHEMBL2547257 0.76 TDP1 (0.45) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL526096 0.74 CYP1A2 (0.43) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL21248477 0.74 MEN1 (0.58) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL10691421 0.73 ALDH1A1 (0.57) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL14876225 0.73 NOTUM (0.47) NOTUML3MBTL1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012014186-A1 PROCESS FOR THE PREPARATION OF SILODOSIN AND ITS NOVEL INTERMEDIATES RANBAXY LABORATORIES LIMITED (IN) 2012-02-02 WO disclosed